Diu Tansin 50mg Tablets

Overview

Diu-Tansin 50mg/12.5mg Tablets Diu Tansin 50mg Tablets is a prescription antihypertensive medicine used for the treatment of high blood pressure when combination therapy is appropriate. The product pack identifies the medicine as Diu-Tansin, a film-coated tablet containing losartan potassium 50 mg and hydrochlorothiazide 12.5 mg. Losartan belongs to the angiotensin II receptor blocker (ARB) class, while hydrochlorothiazide is a thiazide diuretic.

High blood pressure often has no obvious symptoms, but long-term uncontrolled hypertension can increase the risk of stroke, heart disease, kidney problems and other vascular complications. Diu-Tansin should only be used under medical supervision because blood pressure response, kidney function, electrolyte balance and other medicines all influence whether this combination is suitable for an individual patient. Key product details Product nameDiu-Tansin Tablets Active ingredientsLosartan potassium 50 mg + hydrochlorothiazide 12.5 mg Dosage formFilm-coated tablets Pack size shown10 tablets Therapeutic categoryAntihypertensive; ARB and thiazide diuretic combination ManufacturerPharmEvo (Pvt.) Ltd.

Benefits

• Helps lower blood pressure through complementary vascular and diuretic actions
• Losartan helps relax blood vessels by blocking angiotensin II receptor activity
• Hydrochlorothiazide helps remove excess salt and water through the kidneys
• May be used when a clinician considers combination antihypertensive therapy appropriate

Key Features

• Combination of losartan potassium 50 mg and hydrochlorothiazide 12.5 mg
• ARB plus thiazide diuretic antihypertensive formulation
• Film-coated oral tablet
• Pack shown contains 10 tablets
• Manufactured by PharmEvo (Pvt.) Ltd.
• Prescription medicine for use under medical supervision

Dosage and How to Use

• How to use: Take orally with water exactly as prescribed. Do not crush, split or alter the dose unless your doctor or pharmacist instructs you to do so.
• Administration: Oral administration.
• Recommended dose: The usual starting and maintenance dose is one tablet containing losartan potassium 50 mg and hydrochlorothiazide 12.5 mg once daily, as prescribed by a physician.
• Adult dose: Usual adult dose: one 50 mg/12.5 mg tablet once daily as prescribed; may be increased by the physician to two tablets once daily if needed.
• Pediatric use: Safety and effectiveness in children have not been established.
• Elderly use: No initial dosage adjustment is stated as necessary for elderly patients; use under medical supervision with appropriate monitoring.
• When to take: Take once daily at the time advised by your prescriber. Because it contains a diuretic, ask your clinician or pharmacist about the most practical dosing time.
• With food: May be taken with or without food.
• Maximum daily dose: Maximum listed dose: two tablets once daily, only when directed by the prescriber.
• Missed dose: If a dose is missed, ask your pharmacist or doctor for advice. Do not take extra tablets or double the dose to make up for a missed dose unless instructed by a healthcare professional.
• Overdose: Seek urgent medical attention. Management is symptomatic and supportive; suspected overdose may require observation and correction of dehydration, electrolyte imbalance and hypotension.

Specifications

Side Effects

Common side effects

• Dizziness
• Symptoms of low blood pressure such as light-headedness
• Possible increased urination due to hydrochlorothiazide

Serious side effects (seek medical help)

• Anaphylactic reaction or angioedema
• Severe hypotension
• Dehydration or significant electrolyte imbalance
• Changes in kidney function or renal failure in susceptible patients
• Hyperkalemia
• Rare hepatitis or marked liver enzyme elevation
• Severe allergic skin reaction or vasculitis

Allergic reaction

Stop use and seek urgent medical care for swelling of the face, lips, tongue, throat, larynx or glottis, breathing difficulty, hives or other signs of serious hypersensitivity.

Safety and Precautions

• Do not start without medical supervision.
• May cause symptomatic hypotension, especially in volume-depleted patients.
• Kidney function and electrolytes may need monitoring.
• Discontinue and seek medical advice immediately if pregnancy is detected.
• Can cause allergic reactions including angioedema in rare cases.
• Use caution in patients with renal impairment, renal artery stenosis, liver impairment, electrolyte imbalance, diabetes, gout, hypercalcemia, hyperparathyroidism or systemic lupus erythematosus.
• Monitor for dehydration during vomiting, diarrhea or excessive sweating.
• Tell your doctor about all medicines, supplements and salt substitutes you use.

When not to use

Do not use if allergic to losartan, hydrochlorothiazide, any tablet component, or sulfonamide-derived medicines; do not use in anuria. It is not recommended in severe renal impairment or hepatic impairment.

Special populations

• Pregnancy: Avoid use during pregnancy unless a specialist specifically advises otherwise. Drugs acting on the renin-angiotensin system can cause fetal injury and death when used during the second and third trimesters; discontinue as soon as pregnancy is detected and contact a doctor.
• Breastfeeding: Losartan excretion in human milk is not known and thiazides appear in human milk. A healthcare professional should decide whether to discontinue nursing or discontinue the medicine.
• Liver: Not recommended for patients with hepatic impairment.
• Kidney: Not recommended in severe renal impairment, including creatinine clearance below 30 mL/min. Kidney function changes, including renal failure, have been reported in susceptible patients using medicines that affect the renin-angiotensin system.
• Heart: Use under medical supervision in cardiovascular patients. Low blood pressure, fluid imbalance or potassium disturbances may worsen symptoms in susceptible patients; hypokalemia can increase risk of arrhythmia in patients using digitalis.
• Driving: Dizziness or light-headedness may occur. Avoid driving or operating machinery until you know how the medicine affects you.
• Alcohol: Alcohol may increase the risk of orthostatic hypotension with thiazide diuretics; avoid or limit alcohol unless your doctor says otherwise.

Interactions

Drugs:

• Potassium-sparing diuretics such as spironolactone, triamterene or amiloride
• Potassium supplements and potassium-containing salt substitutes
• NSAIDs including indomethacin
• Lithium
• Other antihypertensive medicines
• Antidiabetic medicines including insulin
• Cholestyramine or colestipol resins
• Corticosteroids or ACTH
• Pressor amines such as adrenaline
• Nondepolarizing skeletal muscle relaxants such as tubocurarine
• Rifampin and fluconazole
• Alcohol, barbiturates or narcotics

Food:

• May be taken with or without food. Avoid potassium-containing salt substitutes or potassium supplements unless specifically approved by your prescriber.

Conditions:

• Anuria
• Severe renal impairment
• Hepatic impairment
• Renal artery stenosis or stenosis of the artery to a solitary kidney
• Volume depletion or electrolyte imbalance
• Diabetes
• Gout or hyperuricemia
• Hypercalcemia or suspected hyperparathyroidism
• Systemic lupus erythematosus

Storage and Disposal

• Protect from heat, light and moisture. Store below 30°C.
• Store below 30°C.
• Keep all medicines out of the reach of children.
• Do not use after expiry. Dispose of unused or expired tablets according to local pharmacy or medicine-disposal guidance; do not share medicines with others.

Disclaimer

This information is for product identification and educational purposes only and is not a substitute for medical advice, diagnosis or treatment. Diu-Tansin is a prescription medicine and should be used only as directed by a qualified healthcare professional. Always follow the dosage instructions provided by your physician, pharmacist or product leaflet. Seek immediate medical attention for suspected overdose, pregnancy exposure, severe side effects or allergic reaction.