Valsatril (24/26mg) 14 Tablets

Overview

Valsatril 24/26mg 14 Tablets are an oral prescription medicine containing sacubitril 24mg and valsartan 26mg in each tablet. This fixed-dose combination is used in selected patients with chronic heart failure when prescribed by a qualified healthcare professional. It is not a general heart tonic, a pain-relief tablet, or a medicine to start for chest pain, palpitations, ankle swelling, breathlessness, or fatigue without medical assessment.

Sacubitril and valsartan belong to the angiotensin receptor-neprilysin inhibitor, or ARNI, medicine class. Treatment decisions are individualized because the medicine can affect blood pressure, kidney function, and blood potassium. A prescriber may review current heart medicines, previous ACE inhibitor or ARB therapy, blood pressure, kidney and liver status, electrolyte results, age, dehydration risk, pregnancy status, and history of angioedema before recommending this therapy.

Benefits

• Supports chronic heart failure management when prescribed for suitable patients
• Combines neprilysin inhibition with angiotensin II receptor blockade
• May help reduce strain on the heart through complementary cardiovascular mechanisms
• Can form part of a supervised long-term heart failure treatment plan

Key Features

• Sacubitril 24mg plus valsartan 26mg per tablet
• Angiotensin receptor-neprilysin inhibitor combination
• Pack of 14 oral tablets
• Prescription cardiovascular medicine
• Requires monitoring of blood pressure, kidney function and potassium as directed

Dosage and How to Use

• How to use: Swallow the tablet with water as directed by your prescriber. Do not crush, split, double, stop or change the dose unless instructed by a healthcare professional.
• Administration: Oral administration by tablet; swallow with water as directed.
• Recommended dose: Use exactly as prescribed by your doctor. Dose selection and titration are individualized according to blood pressure, kidney function, potassium level, previous ACE inhibitor or ARB use, age and clinical condition.
• Adult dose: Adult dosing is individualized by the prescriber; this 24/26mg strength may be selected when clinically appropriate for initiation or titration.
• Pediatric use: Use in children only if specifically prescribed and monitored by a pediatric specialist or qualified healthcare professional. Do not give to a child without specialist advice.
• Elderly use: Older adults may need closer monitoring for low blood pressure, dizziness, kidney function changes, dehydration and potassium imbalance.
• When to take: Take at the times prescribed by your doctor, preferably at the same times each day to support consistent therapy.
• With food: May generally be taken with or without food unless your doctor or pharmacist gives different instructions.
• Maximum daily dose: Do not exceed the dose prescribed by your doctor.
• Missed dose: If a dose is missed, follow your prescriber’s instructions. Do not take extra tablets or double the next dose unless specifically advised.
• Overdose: In case of overdose or severe symptoms such as fainting, extreme dizziness, irregular heartbeat, breathing difficulty or marked weakness, seek urgent medical help immediately.

Specifications

Side Effects

Common side effects

• Dizziness
• Low blood pressure
• Cough
• Tiredness or weakness
• Raised potassium level
• Changes in kidney function tests
• Gastrointestinal discomfort

Serious side effects (seek medical help)

• Angioedema or swelling of the face, lips, tongue or throat
• Fainting or severe low blood pressure
• Severe dizziness
• Reduced urination or worsening kidney function
• Symptoms of high potassium such as weakness, palpitations, irregular heartbeat or chest discomfort
• Severe allergic reaction

Allergic reaction

Stop use and seek urgent medical help if swelling of the face, lips, tongue or throat, rash, wheezing or breathing difficulty occurs.

Safety and Precautions

• Do not use without a valid prescription
• May cause low blood pressure, dizziness, kidney function changes or high potassium
• Do not combine with an ACE inhibitor or start too soon after ACE inhibitor therapy unless the prescriber has managed the required washout period
• Seek urgent help for swelling of the face, lips, tongue or throat
• Avoid use during pregnancy unless a specialist gives explicit direction
• Tell your doctor about kidney disease, liver disease, low blood pressure, dehydration, high potassium, diabetes or previous angioedema
• Inform your doctor about all heart, blood pressure, diuretic, lithium, NSAID, potassium and diabetes medicines
• Regular blood pressure, kidney function and potassium monitoring may be required
• Stand up slowly if dizziness occurs
• Do not stop heart failure treatment suddenly without medical advice

When not to use

Allergy to sacubitril, valsartan or any tablet component; concomitant use with ACE inhibitors or use within the required washout period; history of angioedema related to ACE inhibitor or ARB therapy unless a specialist determines otherwise; concomitant aliskiren use in patients with diabetes; pregnancy unless a specialist determines otherwise.

Special populations

• Pregnancy: Not recommended during pregnancy because medicines acting on the renin-angiotensin system can harm the developing baby, especially after the first trimester. Contact a doctor immediately if pregnancy occurs or is planned.
• Breastfeeding: Use while breastfeeding only after medical advice. A healthcare professional should weigh potential benefits and risks and may recommend an alternative.
• Fertility: No product-specific fertility guidance was provided in the input. Ask a healthcare professional if fertility, conception planning or reproductive health is a concern.
• Liver: Patients with liver impairment should use only under medical supervision; dose adjustment or avoidance may be required depending on severity.
• Kidney: May affect kidney function and potassium levels. Patients with kidney disease require medical assessment and monitoring.
• Heart: Use only for diagnosed cardiovascular conditions under supervision. Report worsening breathlessness, swelling, chest discomfort, fainting or irregular heartbeat promptly.
• Driving: May cause dizziness or low blood pressure. Avoid driving or operating machinery until you know how the medicine affects you.
• Alcohol: Alcohol may worsen dizziness or low blood pressure; ask your doctor whether alcohol is safe for your condition.

Interactions

Drugs:

• ACE inhibitors
• Other ARBs or medicines affecting the renin-angiotensin system
• Aliskiren, especially in patients with diabetes
• Potassium supplements or potassium-containing salt substitutes
• Potassium-sparing diuretics such as spironolactone, eplerenone, amiloride or triamterene
• NSAIDs such as ibuprofen, diclofenac or naproxen
• Lithium
• Diuretics and other blood pressure-lowering medicines

Food:

• Potassium-containing salt substitutes may increase potassium risk
• High-potassium intake may need medical guidance in some patients

Conditions:

• History of angioedema
• Low blood pressure or dehydration
• Kidney disease
• Liver impairment
• High potassium levels
• Pregnancy
• Diabetes when using aliskiren

Storage and Disposal

• Store in the original packaging away from heat, moisture and direct sunlight. Do not use expired or damaged tablets.
• Store at room temperature unless the pack label states otherwise; protect from excess heat and moisture.
• Keep out of reach and sight of children and pets.
• Dispose of unused or expired medicine according to pharmacist or local healthcare guidance. Do not throw tablets where children, pets or others may access them.

Disclaimer

This information is for educational and e-commerce purposes only and is not a substitute for medical advice, diagnosis or treatment. Use only as prescribed by a qualified healthcare professional and follow your prescription label and product packaging.