Wondra (50/200mg) 30 Tablets

Overview

Wondra (50/200mg) 30 Tablets is a combination medicine used for selected pain and inflammatory conditions where an NSAID is required together with gastric mucosal protection. The formulation is commonly understood as diclofenac sodium 50 mg with misoprostol 200 mcg per tablet. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that helps reduce pain, swelling and stiffness.

This medicine is not intended for casual or unsupervised use. It has important safety considerations, particularly for pregnancy, gastrointestinal bleeding, heart disease, kidney disease, liver disease, older adults and people taking interacting medicines.

Benefits

• Helps reduce inflammatory pain, swelling and stiffness through diclofenac
• Misoprostol helps support stomach and duodenal mucosal protection during NSAID therapy
• May be useful for selected patients who require diclofenac with additional gastric protection

Key Features

• Contains diclofenac sodium 50 mg and misoprostol 200 mcg per tablet
• NSAID plus prostaglandin analogue combination
• Oral tablet dosage form
• 30-tablet pack
• Used for inflammatory pain and NSAID-associated ulcer risk reduction when prescribed

Dosage and How to Use

• How to use: Swallow the tablet whole with water. Do not crush, chew or split unless a pharmacist confirms it is appropriate for the supplied tablet. Follow the prescription label exactly.
• Administration: Oral administration only.
• Recommended dose: Use only at the dose and frequency prescribed by a qualified healthcare professional. Do not self-adjust the dose.
• Adult dose: Individualized by the prescriber according to condition, risk factors and response.
• Pediatric use: Not recommended for children unless specifically prescribed and supervised by a specialist.
• Elderly use: Older adults may have higher risk of gastrointestinal bleeding, kidney problems, fluid retention and cardiovascular events; use requires careful medical supervision.
• When to take: Usually taken with food or after meals to reduce stomach discomfort, unless the prescriber gives different instructions.
• With food: Preferably with or after food, unless directed otherwise.
• Maximum daily dose: Do not exceed the maximum daily dose prescribed by the doctor or stated on the dispensed prescription label.
• Missed dose: If a dose is missed, take it when remembered unless it is nearly time for the next dose. Do not take two doses together to make up for a missed dose.
• Overdose: Seek urgent medical help or contact a poison control service immediately. Overdose may cause severe stomach symptoms, bleeding, drowsiness, dizziness, breathing difficulty, kidney problems or seizures.

Specifications

Side Effects

Common side effects

• Abdominal pain
• Indigestion
• Nausea
• Diarrhoea
• Flatulence
• Headache
• Dizziness
• Fluid retention
• Menstrual cramps or abnormal bleeding

Serious side effects (seek medical help)

• Gastrointestinal bleeding or ulceration
• Black stools or vomiting blood
• Heart attack or stroke symptoms
• Severe allergic reaction
• Severe skin reaction
• Kidney problems
• Liver injury
• Severe persistent diarrhoea

Allergic reaction

Stop use and seek urgent help for rash, swelling of the face or throat, wheezing, severe dizziness, blistering skin reaction or breathing difficulty.

Safety and Precautions

• Do not use during pregnancy.
• May increase risk of serious gastrointestinal bleeding, ulceration or perforation.
• May increase risk of heart attack, stroke, fluid retention or raised blood pressure.
• Avoid combining with other NSAIDs unless specifically directed.
• Seek urgent care for chest pain, breathing difficulty, black stools, vomiting blood, severe abdominal pain or allergic swelling.
• Use the lowest effective dose for the shortest appropriate duration as advised by the prescriber.
• Tell the doctor about previous stomach ulcer, bleeding disorder, heart disease, hypertension, kidney disease, liver disease, asthma or inflammatory bowel disease.
• Inform the doctor about all prescription medicines, OTC medicines and supplements before use.
• Women who may become pregnant should discuss contraception and pregnancy-related precautions before use.

When not to use

Known allergy to diclofenac, misoprostol, aspirin or other NSAIDs | Pregnancy | History of NSAID-induced asthma, urticaria or serious allergic reaction | Active serious gastrointestinal bleeding unless specifically assessed by a specialist | Use around coronary artery bypass graft surgery

Special populations

• Pregnancy: Contraindicated in pregnancy. Misoprostol can cause uterine contractions, miscarriage, premature birth or birth defects, and NSAIDs may harm the fetus, especially later in pregnancy.
• Breastfeeding: Use during breastfeeding only if a healthcare professional determines it is appropriate, considering the medicine combination and infant risk.
• Fertility: NSAIDs may temporarily impair female fertility. Women trying to conceive should discuss alternatives with a doctor.
• Liver: Use cautiously in liver disease. Stop and seek medical advice for yellowing of skin or eyes, dark urine, severe fatigue or persistent nausea.
• Kidney: NSAIDs can worsen kidney function, especially in dehydration, older age, kidney disease, heart failure or with diuretics, ACE inhibitors or ARBs.
• Heart: NSAIDs may increase the risk of heart attack, stroke, high blood pressure, fluid retention and worsening heart failure, particularly with higher doses or longer use.
• Driving: May cause dizziness, drowsiness or visual disturbance in some users. Avoid driving or operating machinery if affected.
• Alcohol: Alcohol may increase the risk of stomach irritation and bleeding with NSAIDs; avoid or limit alcohol during treatment.

Interactions

Drugs:

• Other NSAIDs including aspirin used for pain relief
• Blood thinners such as warfarin or DOACs
• Antiplatelet medicines
• Corticosteroids
• SSRIs or SNRIs
• ACE inhibitors, ARBs and diuretics
• Lithium
• Methotrexate
• Cyclosporine or tacrolimus
• Digoxin

Food:

• Food may reduce stomach discomfort. Alcohol can increase gastrointestinal irritation and bleeding risk.

Conditions:

• Peptic ulcer disease or gastrointestinal bleeding
• Cardiovascular disease, hypertension or heart failure
• Kidney impairment
• Liver impairment
• Asthma sensitive to aspirin or NSAIDs
• Bleeding disorders
• Inflammatory bowel disease

Storage and Disposal

• Store in the original packaging, protected from moisture, direct heat and sunlight. Follow the storage temperature stated on the pack.
• Follow the temperature requirement printed on the product pack.
• Keep out of the reach and sight of children and pets.
• Do not use expired or damaged tablets. Return unused medicine to a pharmacy take-back service where available; do not share with others.

Disclaimer

This information is for educational product content only and is not a substitute for medical advice, diagnosis or treatment. Use only as directed by a qualified healthcare professional or the approved product label.