Zamlo H Tablets

Overview

Zamlo-H Tablets are an antihypertensive medicine containing amlodipine 5 mg and hydrochlorothiazide 12.5 mg. This combination is used for the management of high blood pressure when a clinician considers dual therapy appropriate. Amlodipine belongs to the calcium channel blocker class, while hydrochlorothiazide is a thiazide diuretic.

High blood pressure often has no obvious symptoms, but uncontrolled hypertension can increase the risk of stroke, heart attack, heart failure, kidney disease and other vascular complications. Zamlo-H should be used as part of a wider blood pressure plan that may include salt reduction, weight management, regular monitoring, exercise, smoking cessation and follow-up with a healthcare professional.

Benefits

• Helps lower elevated blood pressure when used as prescribed
• Amlodipine relaxes blood vessels to reduce vascular resistance
• Hydrochlorothiazide helps remove excess salt and water through urine
• May support long-term cardiovascular risk reduction as part of a complete hypertension plan

Key Features

• Contains amlodipine 5 mg and hydrochlorothiazide 12.5 mg
• Combination of a calcium channel blocker and thiazide diuretic
• Tablet dosage form
• Used for hypertension management when clinically appropriate
• Manufactured by Zafa Pharmaceutical Laboratories (Pvt.) Ltd.

Dosage and How to Use

• How to use: Swallow the tablet with water. Take it consistently at the time advised by your prescriber and do not crush or split unless instructed.
• Administration: Oral administration; swallow with water.
• Recommended dose: Use exactly as prescribed by a doctor. The dose and dosing frequency depend on blood pressure response, medical history and other medicines.
• Adult dose: Adults should take only the dose and schedule prescribed by a registered medical practitioner.
• Pediatric use: Not recommended for children unless specifically prescribed and supervised by a specialist.
• Elderly use: Older adults may need closer blood pressure, kidney function and electrolyte monitoring due to higher sensitivity to dizziness, dehydration and falls.
• When to take: Take at the time recommended by your doctor. Because it contains a diuretic, it is often taken earlier in the day if advised, to reduce night-time urination.
• With food: May be taken with or without food unless your doctor or product label advises otherwise. Take it consistently the same way each day.
• Maximum daily dose: Do not exceed the dose prescribed by your doctor.
• Missed dose: Take the missed dose when remembered unless it is nearly time for the next dose. Do not take two doses together to make up for a missed dose.
• Overdose: Seek urgent medical help or contact a poison control centre if overdose is suspected, especially with severe dizziness, fainting, weakness, confusion, very low blood pressure or abnormal heartbeat.

Specifications

Side Effects

Common side effects

• Dizziness
• Light-headedness
• Headache
• Flushing
• Ankle or foot swelling
• Increased urination
• Tiredness
• Nausea or stomach discomfort
• Electrolyte changes

Serious side effects (seek medical help)

• Fainting or severe low blood pressure
• Chest pain or worsening angina
• Rapid or irregular heartbeat
• Severe dehydration
• Very low urine output
• Confusion or severe weakness
• Severe allergic reaction
• Severe electrolyte imbalance

Allergic reaction

Seek urgent medical help for swelling of the face, lips, tongue or throat, breathing difficulty, severe rash, hives or other signs of a serious allergic reaction.

Safety and Precautions

• May cause dizziness or light-headedness, particularly when standing up
• May alter electrolytes, uric acid, blood sugar or kidney function
• Do not stop suddenly without medical advice
• Use with caution in dehydration, kidney disease, liver disease, heart disease, gout or diabetes
• Monitor blood pressure regularly
• Tell your doctor about all prescription, OTC and herbal medicines
• Maintain adequate hydration unless fluid restriction has been advised
• Rise slowly from sitting or lying positions to reduce dizziness

When not to use

Do not use in case of hypersensitivity to amlodipine, hydrochlorothiazide or any tablet ingredient. Avoid use in anuria and use only with specialist advice in severe hypotension, severe electrolyte imbalance or significant kidney/liver disease.

Special populations

• Pregnancy: Use during pregnancy only if prescribed by a qualified healthcare professional. Do not self-medicate for blood pressure in pregnancy.
• Breastfeeding: Consult a doctor before use while breastfeeding, as treatment choice should consider infant safety and maternal blood pressure needs.
• Fertility: No product-specific fertility information was provided. Consult a healthcare professional if planning pregnancy or having fertility concerns.
• Liver: Use with caution and medical monitoring in liver disease, as amlodipine exposure and blood pressure effects may be altered.
• Kidney: Use with caution in kidney disease. Hydrochlorothiazide may affect fluid balance, electrolytes and kidney function monitoring.
• Heart: Use under medical supervision in heart failure, severe coronary artery disease, aortic stenosis, very low blood pressure or recent cardiovascular events.
• Driving: May cause dizziness, sleepiness or light-headedness. Avoid driving or operating machinery until you know how the medicine affects you.
• Alcohol: Alcohol may increase dizziness or blood pressure-lowering effects. Avoid or limit alcohol unless your doctor says it is safe.

Interactions

Drugs:

• Other blood pressure medicines
• Diuretics
• Lithium
• NSAID pain relievers
• Digoxin
• Corticosteroids
• Potassium supplements or potassium-altering medicines
• CYP3A4 inhibitors or inducers
• Simvastatin and other medicines requiring dose review

Food:

• Discuss grapefruit intake with your doctor or pharmacist because grapefruit may affect some calcium channel blockers. Follow any salt, fluid or diet advice given for hypertension.

Conditions:

• Kidney impairment
• Liver impairment
• Heart failure
• Severe hypotension
• Electrolyte imbalance
• Gout
• Diabetes
• Lupus
• Dehydration

Storage and Disposal

• Store at room temperature away from heat, moisture and direct sunlight. Keep in original packaging until use.
• Room temperature; protect from excessive heat and moisture.
• Keep out of reach and sight of children and pets.
• Dispose of expired or unused tablets through a pharmacy or local medicine disposal guidance. Do not flush medicines or leave loose tablets accessible.

Disclaimer

This information is for educational product content only and is not a substitute for medical advice, diagnosis or treatment. Use only as directed by a qualified healthcare professional and seek urgent care for severe side effects, allergic reaction or overdose.