Ziabex-M (50/1000Mg) 14 Tablets

Overview

Ziabex-M 50/1000mg Tablets are an oral antidiabetic medicine containing two complementary active ingredients: vildagliptin 50mg and metformin hydrochloride 1000mg. The combination is used for adults with type 2 diabetes mellitus when diet, exercise and single-agent therapy do not provide adequate blood glucose control, or when a clinician decides that dual therapy is appropriate. Each retail pack contains 14 tablets, commonly supplied as two strips of seven tablets.

This product is intended to support long-term glycaemic control as part of a complete diabetes plan that also includes meal planning, physical activity, glucose monitoring and regular medical follow-up. It is not an insulin substitute and is not used for type 1 diabetes or diabetic ketoacidosis.

Benefits

• Supports fasting and post-meal blood glucose control in type 2 diabetes
• Combines two complementary glucose-lowering mechanisms
• May reduce hepatic glucose production and improve insulin sensitivity
• May enhance glucose-dependent insulin response through DPP-4 inhibition

Key Features

• Vildagliptin 50mg plus Metformin HCl 1000mg fixed-dose combination
• Oral tablet dosage form
• Pack of 14 tablets
• DPP-4 inhibitor and biguanide antidiabetic combination
• Used as part of diet, exercise and blood glucose monitoring plan

Dosage and How to Use

• How to use: Swallow the tablet whole with a glass of water. Do not crush, chew or split unless your doctor or pharmacist specifically advises it. Continue diet, exercise and glucose monitoring as recommended.
• Administration: Oral administration.
• Recommended dose: Use exactly as prescribed. A commonly referenced adult regimen for vildagliptin/metformin 50/1000mg combinations is one tablet in the morning and one tablet in the evening with or just after food, but the patient-specific dose must be decided by a doctor.
• Adult dose: Patient-specific. Follow the prescriber’s instructions; many vildagliptin/metformin 50/1000mg regimens use one tablet twice daily with meals when suitable.
• Pediatric use: Not recommended for children and adolescents under 18 years unless specifically advised by a specialist.
• Elderly use: Use with caution in older adults. Kidney function should be checked before and during treatment, as metformin-related lactic acidosis risk increases when renal function is reduced.
• When to take: Usually taken with meals or immediately after meals to reduce gastrointestinal side effects associated with metformin. Follow the timing prescribed by your doctor.
• With food: Take with food or just after food unless your doctor advises otherwise.
• Maximum daily dose: Do not exceed the dose prescribed by your doctor. The maximum appropriate daily dose depends on kidney function, previous therapy and clinical response.
• Missed dose: Take the missed dose with your next meal unless it is almost time for the next scheduled dose. Do not take a double dose to make up for a missed tablet.
• Overdose: Seek medical advice or emergency care immediately if too many tablets are taken. Take the medicine pack with you. Overdose may require monitoring for lactic acidosis, hypoglycaemia and gastrointestinal symptoms.

Specifications

Side Effects

Common side effects

• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain or discomfort
• Flatulence or heartburn
• Constipation
• Headache
• Dizziness
• Sore throat or runny nose
• Sweating, trembling or low blood glucose when combined with other diabetes medicines
• Metallic taste
• Loss of appetite
• Tiredness or weakness
• Itchy rash or joint pain

Serious side effects (seek medical help)

• Lactic acidosis
• Pancreatitis
• Angioedema or serious allergic reaction
• Liver injury or hepatitis
• Severe hypoglycaemia, especially with insulin or sulfonylureas
• Vitamin B12 deficiency with long-term metformin use

Allergic reaction

Do not take if you have had an allergic reaction to vildagliptin, metformin or any tablet ingredient. Seek urgent help for swelling of the face, lips, tongue or throat, rash, hives or breathing difficulty.

Safety and Precautions

• Risk of rare but serious lactic acidosis, especially with reduced kidney function, dehydration, severe infection, excessive alcohol intake or conditions causing low oxygen supply
• Not for type 1 diabetes or diabetic ketoacidosis
• May need temporary interruption before iodinated contrast imaging or major surgery
• Report symptoms of pancreatitis, liver injury or serious allergy urgently
• Tell your doctor about kidney, liver, heart or pancreatic disease
• Inform your doctor about all prescription medicines, OTC medicines and supplements
• Monitor blood glucose as advised
• Follow diabetic diet and exercise guidance
• Avoid dehydration and seek advice during severe vomiting, diarrhoea or fever

When not to use

Allergy to vildagliptin, metformin or tablet ingredients | Diabetic ketoacidosis | Severely reduced kidney function | Severe infection or serious dehydration | Serious heart, circulation or breathing problems associated with tissue hypoxia | Severe liver disease | Acute alcohol intoxication or alcoholism | Pregnancy or breastfeeding unless a doctor specifically decides otherwise

Special populations

• Pregnancy: Do not use during pregnancy unless a doctor specifically decides that the benefit outweighs the risk. Consult a healthcare professional if pregnant, planning pregnancy or pregnancy is suspected.
• Breastfeeding: Use during breastfeeding is generally not recommended unless a healthcare professional specifically advises otherwise.
• Fertility: No product-specific fertility advice is provided in the input. Discuss fertility concerns and pregnancy planning with a doctor before use.
• Liver: Use is not recommended in severe liver disease. Liver function may need testing before and during treatment; seek advice for yellowing of the skin or eyes, dark urine, severe nausea or unexplained loss of appetite.
• Kidney: Kidney function should be assessed before and during treatment. Reduced kidney function increases the risk of metformin accumulation and lactic acidosis.
• Heart: Use caution in patients with recent heart attack, heart failure, serious circulation problems or breathing difficulty. Seek medical advice before use.
• Driving: If you feel dizzy or experience symptoms of low blood glucose, do not drive or operate machinery until you feel well and glucose is controlled.
• Alcohol: Avoid excessive alcohol intake because it can increase the risk of lactic acidosis with metformin-containing medicines.

Interactions

Drugs:

• Insulin or sulfonylureas may increase hypoglycaemia risk
• Diuretics, NSAIDs, COX-2 inhibitors, ACE inhibitors and angiotensin II receptor blockers may affect kidney function
• Iodinated contrast agents may require temporary interruption
• Glucocorticoids and beta-2 agonists may affect blood glucose control
• Cimetidine, ranolazine, dolutegravir and vandetanib may require monitoring or dose review
• Other antidiabetic medicines may require dose adjustment

Food:

• Take with meals or just after meals. Avoid excessive alcohol. Follow the diabetic meal plan and carbohydrate guidance provided by your healthcare professional.

Conditions:

• Type 1 diabetes
• Diabetic ketoacidosis
• Severe renal impairment
• Severe liver disease
• Severe dehydration
• Severe infection
• Heart failure or recent myocardial infarction
• Conditions causing reduced oxygen supply
• Pancreatic disease or history of pancreatitis
• Alcoholism

Storage and Disposal

• Store in the original packaging, protected from heat, light and moisture.
• Store below 30°C.
• Keep out of the sight and reach of children.
• Do not use expired tablets. Ask a pharmacist how to dispose of unused medicine safely; do not dispose of medicines through wastewater where proper return options are available.

Disclaimer

For informational and cataloguing purposes only. Not a substitute for professional medical advice. Use only as directed by a qualified healthcare professional and seek urgent medical help for serious side effects, allergic reaction, suspected lactic acidosis, pancreatitis, liver injury or overdose.